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Earlier detection of memory loss and dementia.

The world’s LARGEST standardized neuroscientific database.

NeuralScan Memory Loss - Brain Frequencies

Upwards of 20% of individuals age 65 and older already have detectable symptoms of mild cognitive impairment; however, diagnosing the cause of memory loss can prove challenging. Historically, many doctors have relied on self-report questionnaires and effort-based computerized testing for determining a diagnosis; however, even when used in optimal conditions, these assessments often fall short in the detection of early or less severe disease presentations. Additionally, current tools lack the sensitivity and objectivity needed to develop accurate diagnoses, resulting in misdiagnosis in a segment of the patient population. Therefore, when patients present with concerns of memory loss, the physician needs a quick, easy-to-use, low-cost, objective, and sensitive test.

Electroencephalography (EEG) has been employed extensively in clinical research and provides a non-invasive and office-based solution for objectively measuring brain function. Leading research agrees that clinical evaluation along with other supportive diagnostic techniques, such as functional neuroimaging, may be necessary to substantiate memory loss diagnoses; however, since the sensitive equipment needed is expensive and data interpretation can be difficult and time-consuming, the EEG has historically been out of reach for many practicing physicians.

NeuralScan can help physicians to diagnose:

  • Detect memory loss and MCI sooner
  • Identify the root cause of memory loss
  • Perform differential diagnosis of dementia vs. pseudo-dementia

Peak Frequency

The alpha frequency band (8 – 12 Hz) is the most dominant EEG frequency found in the brain. The Peak Alpha Frequency (PAF), or posterior dominant rhythm, is largely generated by the thalamus and reflects thalamo-cortical network activity; therefore, PAF can be conceptualized as the pacemaker of the brain and is known to be a good measure of information processing capacity.

EEG studies have found that PAF rises from childhood to adolescence, and then decreases slowly around 11 years old. Regardless of age, individuals with strong working memory abilities have faster PAF compared to inferior memory performers. Abnormally low PAF (< 8 Hz) can be found in patients with cognitive disturbances and dementia, while a slowed PAF is correlated with the loss of hippocampal volume in many posterior regions of the brain in individuals suffering from MCI. The PAF electrophysiology biomarker can, therefore, be used to help identify patients with preclinical dementia and monitor a patient’s overall cognitive capacity over time.

Peak frequency is a statistic that tells us what the frequency within a band was that had the highest amplitude. For example, in the alpha band (8-12 Hz), 10 Hz should be highest in most adults. Values rising above that may result in problems experienced by the client, depending on where we see this, and peaks below 10 can often result in cognitive difficulties, word-finding problems, etc. The TQ shows you peaks in alpha, beta and the overall peak. Looking at the three together, once you understand more about the EEG and the assessment.

Earlier detection of memory loss and dementia.